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rdf:type |
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lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0026809,
umls-concept:C0027882,
umls-concept:C0071163,
umls-concept:C0221099,
umls-concept:C0332307,
umls-concept:C0597357,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
2003-8-5
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pubmed:abstractText |
The role of pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor (PAC1 receptor) in regulating hypothalamic supraoptic neurones was investigated using PAC1 receptor-deficient male mice (PAC1-/-). The effects of PACAP on [Ca2+]i were investigated in freshly dissociated supraoptic neurones and on the somatodendritic release of vasopressin and oxytocin, examined on intact supraoptic nuclei. In supraoptic neurones from wild-type mice (PAC1+/+), 100 nm PACAP induced an increase in [Ca2+]i and release of vasopressin and oxytocin, whereas in heterozygous (PAC1+/-) and null-mutant mice (PAC1-/-), PACAP was much less effective. PACAP had no effect on these two parameters when applied to isolated neurohypophysial nerve terminals of PAC1+/+ and PAC1-/- mice, and rats. In conclusion, the PAC1 receptor is solely responsible for the PACAP-induced [Ca2+]i signalling and secretion of vasopressin and oxytocin in the somatodendritic region of supraoptic neurones.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adcyap1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Adcyap1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Adcyap1r1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Adcyap1r1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxytocin,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Vasopressins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0953-8194
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
871-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12899682-Animals,
pubmed-meshheading:12899682-Calcium,
pubmed-meshheading:12899682-Calcium Signaling,
pubmed-meshheading:12899682-Dendrites,
pubmed-meshheading:12899682-Intracellular Membranes,
pubmed-meshheading:12899682-Male,
pubmed-meshheading:12899682-Mice,
pubmed-meshheading:12899682-Mice, Knockout,
pubmed-meshheading:12899682-Nerve Endings,
pubmed-meshheading:12899682-Neurons,
pubmed-meshheading:12899682-Neuropeptides,
pubmed-meshheading:12899682-Osmolar Concentration,
pubmed-meshheading:12899682-Oxytocin,
pubmed-meshheading:12899682-Pituitary Adenylate Cyclase-Activating Polypeptide,
pubmed-meshheading:12899682-Pituitary Gland, Posterior,
pubmed-meshheading:12899682-Protein Isoforms,
pubmed-meshheading:12899682-Rats,
pubmed-meshheading:12899682-Rats, Wistar,
pubmed-meshheading:12899682-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:12899682-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:12899682-Receptors, Pituitary Hormone,
pubmed-meshheading:12899682-Supraoptic Nucleus,
pubmed-meshheading:12899682-Vasopressins
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pubmed:year |
2003
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pubmed:articleTitle |
Impaired somatodendritic responses to pituitary adenylate cyclase-activating polypeptide (PACAP) of supraoptic neurones in PACAP type I -receptor deficient mice.
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pubmed:affiliation |
UPR 9023-CNRS and UMR 5101-CNRS, CCIPE, Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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