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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2003-8-20
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pubmed:abstractText |
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-10047442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-10385523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-10570484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-10619425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-10747087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-11001058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-11001059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-11237004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-11959998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-12213837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-12221135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-12453154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-1537327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-2188733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-2194670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-3545499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-7068762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-7774590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-7923363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-8004676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-8221884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-8334998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-8455717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-8612273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9089287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9096343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9166403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9211930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9214619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9482879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9529252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9580559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9755865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9759724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9813082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9844642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9857067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12893879-9861047
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9873-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12893879-Amino Acid Sequence,
pubmed-meshheading:12893879-Biological Transport, Active,
pubmed-meshheading:12893879-Endoplasmic Reticulum,
pubmed-meshheading:12893879-Genome, Fungal,
pubmed-meshheading:12893879-Membrane Proteins,
pubmed-meshheading:12893879-Molecular Sequence Data,
pubmed-meshheading:12893879-Qc-SNARE Proteins,
pubmed-meshheading:12893879-SNARE Proteins,
pubmed-meshheading:12893879-Saccharomyces cerevisiae,
pubmed-meshheading:12893879-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:12893879-Sequence Homology, Amino Acid,
pubmed-meshheading:12893879-Vesicular Transport Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
A SNARE required for retrograde transport to the endoplasmic reticulum.
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pubmed:affiliation |
Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3010, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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