Linked Life Data

12880685

Source:http://linkedlifedata.com/resource/pubmed/id/12880685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-7-25
pubmed:abstractText
It remains unclear which cells present fed antigen and whether their phenotype and/or activation state differs between oral tolerance and priming. Furthermore, it is also controversial whether the presentation occurs locally in the gut and/or systemically. Clarifying these issues will be important for the design and use of oral vaccines, the therapeutic use of oral tolerance and understanding of IBD. Previous studies using activation of T cell receptor transgenic T cells to compare local and systemic distribution of fed antigen have yielded conflicting results. We have therefore employed the C4H3 antibody, specific for HEL peptide (46-61) in the context of I-Ak, to examine antigen distribution in oral tolerance and priming. Our studies indicate that immunologically relevant antigen can be detected in both local and systemic lymphoid tissue soon after feeding antigen in tolerogenic or immunogenic forms. Furthermore, targeting fed antigen to BcR tg B cells via their specific B cell receptor also results in local and systemic presentation and leads to up-regulation of costimulatory molecules on these cells that suggests their role in presentation of the fed antigen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-55
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
An investigation of the distribution of antigen fed in tolerogenic or immunogenic forms.
pubmed:affiliation
Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow, G11 6NT, UK.
pubmed:publicationType
Journal Article