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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-7-22
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pubmed:abstractText |
Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-9942
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pubmed:author |
pubmed-author:AllenFred HFHJr,
pubmed-author:BoozeMichael WMW,
pubmed-author:GoetzChristopher GCG,
pubmed-author:HainesJonathan LJL,
pubmed-author:HinerBradley CBC,
pubmed-author:HubbleJean PJP,
pubmed-author:JankovicJosephJ,
pubmed-author:KollerWilliam CWC,
pubmed-author:LyonsKelly EKE,
pubmed-author:MartinEden RER,
pubmed-author:MastagliaFrank LFL,
pubmed-author:MiddletonLefkos TLT,
pubmed-author:NanceMartha AMA,
pubmed-author:OliveiraSofia ASA,
pubmed-author:OndoWilliam GWG,
pubmed-author:PahwaRajeshR,
pubmed-author:Pericak-VanceMargaret AMA,
pubmed-author:ReavesJoshua AJA,
pubmed-author:ScottBurton LBL,
pubmed-author:ScottWilliam KWK,
pubmed-author:SmallGary WGW,
pubmed-author:StajichJeffrey MJM,
pubmed-author:SternMatthew BMB,
pubmed-author:VanceJeffery MJM,
pubmed-author:WattsRay LRL,
pubmed-author:ZhangFengyuF
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
975-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12873854-Adolescent,
pubmed-meshheading:12873854-Adult,
pubmed-meshheading:12873854-Aged,
pubmed-meshheading:12873854-Alleles,
pubmed-meshheading:12873854-Female,
pubmed-meshheading:12873854-Genetic Predisposition to Disease,
pubmed-meshheading:12873854-Genotype,
pubmed-meshheading:12873854-Haplotypes,
pubmed-meshheading:12873854-Humans,
pubmed-meshheading:12873854-Ligases,
pubmed-meshheading:12873854-Male,
pubmed-meshheading:12873854-Middle Aged,
pubmed-meshheading:12873854-Parkinson Disease,
pubmed-meshheading:12873854-Polymerase Chain Reaction,
pubmed-meshheading:12873854-Polymorphism, Single Nucleotide,
pubmed-meshheading:12873854-Ubiquitin-Protein Ligases
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pubmed:year |
2003
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pubmed:articleTitle |
Association study of Parkin gene polymorphisms with idiopathic Parkinson disease.
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pubmed:affiliation |
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
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