Linked Life Data

12858228

Source:http://linkedlifedata.com/resource/pubmed/id/12858228

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-7-14
pubmed:abstractText
Stratum corneum (SC) hydration is partially regulated by water-soluble molecules, natural moisturizing factor (NMF) that is associated with the corneocytes. Routine water exposure, e.g., bathing, may deplete NMF and alter the SC water-handling properties. We determined the effects of bathing and solvent extraction on the volar forearm skin of eleven healthy volunteers. Acetone/ether (A/E) was used to remove surface and upper SC lipids. Adjacent sites were soaked for ten minutes or treated with the A/E-plus-soak combination. Subsequently, an NMF formulation was applied to the treated sites, and transepidermal water loss (TEWL), hydration, and moisture accumulation rate (MAT) were measured. A/E extraction increased TEWL, but did not effect MAT. Soaking produced a short-term increase in TEWL, followed by a decrease, and substantially reduced MAT, an effect that was maintained for five hours. NMF application significantly decreased TEWL and significantly increased MAT for all sites. The replacement experiment suggests that the MAT reduction occurred as a result of extraction of hygroscopic NMF components. The effects of soaking and NMF application are more readily detected by the MAT technique, whereas TEWL is more sensitive to A/E extraction. The results support the use of multiple assessments of barrier function and raise questions about the effects of cumulative repeated water exposure on SC function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1525-7886
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-300
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Effect of soaking and natural moisturizing factor on stratum corneum water-handling properties.
pubmed:affiliation
The Skin Sciences Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA.
pubmed:publicationType
Journal Article, Clinical Trial