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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-7-11
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pubmed:abstractText |
Fetal loss syndrome (abortion/resorption) occurring on or after gestation day (gd) 9.5 in CBA/JxDBA/2 matings is dependent upon presence of TNF-alpha + IFN-gamma, which act by increasing expression of fg12 prothrombinase at the feto-maternal interface. The magnitude by which the abortion rate can be boosted by an injection of these cytokines on gd 7.5 depends on endogenous rate of loss, and appears to depend on microbial flora. Is cytokine-triggered abortion dependent upon a third signaling pathway that senses 'danger'?
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1046-7408
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-307
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pubmed:dateRevised |
2005-7-27
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pubmed:meshHeading |
pubmed-meshheading:12854734-Abortion, Spontaneous,
pubmed-meshheading:12854734-Animals,
pubmed-meshheading:12854734-Antigens, Surface,
pubmed-meshheading:12854734-Cytokines,
pubmed-meshheading:12854734-Female,
pubmed-meshheading:12854734-Male,
pubmed-meshheading:12854734-Membrane Glycoproteins,
pubmed-meshheading:12854734-Mice,
pubmed-meshheading:12854734-Mice, Inbred BALB C,
pubmed-meshheading:12854734-Mice, Inbred C57BL,
pubmed-meshheading:12854734-Mice, Inbred CBA,
pubmed-meshheading:12854734-Mice, Inbred DBA,
pubmed-meshheading:12854734-Pregnancy,
pubmed-meshheading:12854734-Signal Transduction,
pubmed-meshheading:12854734-Th1 Cells
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pubmed:year |
2003
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pubmed:articleTitle |
MD-1 is a critical part of the mechanism causing Th1-cytokine-triggered murine fetal loss syndrome.
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pubmed:affiliation |
Department of Medicine, McMaster University, Hamilton, Ontario, Canada. clarkd@mcmaster.ca
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pubmed:publicationType |
Journal Article
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