rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
15
|
pubmed:dateCreated |
2003-7-10
|
pubmed:abstractText |
The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
4
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2449-53
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12852941-4-Butyrolactone,
pubmed-meshheading:12852941-Bacterial Proteins,
pubmed-meshheading:12852941-Cyclization,
pubmed-meshheading:12852941-Dose-Response Relationship, Drug,
pubmed-meshheading:12852941-Drug Design,
pubmed-meshheading:12852941-Genes, Reporter,
pubmed-meshheading:12852941-Indicators and Reagents,
pubmed-meshheading:12852941-Lactones,
pubmed-meshheading:12852941-Peptides,
pubmed-meshheading:12852941-Signal Transduction,
pubmed-meshheading:12852941-Staphylococcus,
pubmed-meshheading:12852941-Structure-Activity Relationship,
pubmed-meshheading:12852941-Trans-Activators,
pubmed-meshheading:12852941-Tyrosine
|
pubmed:year |
2003
|
pubmed:articleTitle |
Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.
|
pubmed:affiliation |
School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|