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pubmed-article:12851279pubmed:abstractTextThe expression and release of tissue factor is a major trigger for the activation of coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibition of thrombin generation and fibrin formation.lld:pubmed
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pubmed-article:12851279pubmed:articleTitleEfficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.lld:pubmed
pubmed-article:12851279pubmed:affiliationDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA. edward.abraham@uchsc.edulld:pubmed
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