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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-9
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pubmed:abstractText |
The expression and release of tissue factor is a major trigger for the activation of coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibition of thrombin generation and fibrin formation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1538-3598
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pubmed:author |
pubmed-author:AbrahamEdwardE,
pubmed-author:ArtigasAntonioA,
pubmed-author:BealeRichardR,
pubmed-author:CreaseyAbla AAA,
pubmed-author:De DeyneCathyC,
pubmed-author:DemeyerIgnaceI,
pubmed-author:DoigChristopherC,
pubmed-author:LaterrePierre FrancoisPF,
pubmed-author:LightBruceB,
pubmed-author:OPTIMIST Trial Study Group,
pubmed-author:OpalStevenS,
pubmed-author:PeckelsenClausC,
pubmed-author:PercellSandra RSR,
pubmed-author:PettiläVilleV,
pubmed-author:PooleLonaL,
pubmed-author:PostierRussellR,
pubmed-author:ReinhartKonradK,
pubmed-author:RodriguezAngel LópezAL,
pubmed-author:SeibertAllanA,
pubmed-author:ShuVincentV,
pubmed-author:SimonStuartS,
pubmed-author:SpapenHerbertH,
pubmed-author:StolzenbachJames CJC,
pubmed-author:StoneJudyJ,
pubmed-author:SvobodaPetrP,
pubmed-author:TobiasJeffreyJ,
pubmed-author:ZwingelsteinChristianC
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238-47
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12851279-Anticoagulants,
pubmed-meshheading:12851279-Double-Blind Method,
pubmed-meshheading:12851279-Drug Interactions,
pubmed-meshheading:12851279-Female,
pubmed-meshheading:12851279-Heparin,
pubmed-meshheading:12851279-Humans,
pubmed-meshheading:12851279-International Normalized Ratio,
pubmed-meshheading:12851279-Lipoproteins,
pubmed-meshheading:12851279-Male,
pubmed-meshheading:12851279-Middle Aged,
pubmed-meshheading:12851279-Proteins,
pubmed-meshheading:12851279-Recombinant Proteins,
pubmed-meshheading:12851279-Survival Analysis,
pubmed-meshheading:12851279-Systemic Inflammatory Response Syndrome
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pubmed:year |
2003
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pubmed:articleTitle |
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.
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pubmed:affiliation |
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA. edward.abraham@uchsc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
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