Source:http://linkedlifedata.com/resource/pubmed/id/12851244
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-7-9
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| pubmed:abstractText |
Local and systemic inflammation has been implicated in the pathogenesis of acute pancreatitis and secondary multisystem organ failure. To assess the pro- and antiinflammatory response, the site of mediator production, and their route of diffusion, we sampled simultaneously ascites, thoracic lymph, and blood at the onset of end-organ dysfunction and for the following 6 days in 60 patients with acute pancreatitis. We used immunoassays to measure pro- and antiinflammatory cytokines and cell-based bioassays to assess the net pro- and antiinflammatory activity elicited by the biological fluids. Tumor necrosis factor-alpha and interleukin-1beta were detected in less than 15% of blood and lymph samples. Secondary pro- and antiinflammatory cytokines were found to be elevated early and throughout the sampling period in all compartments. Cytokine levels decreased from ascites to lymph to blood, suggesting a splanchnic origin. Prolonged diversion of ascites and lymph did not alter cytokine gradients, suggesting mediator transfer via the splanchnic blood circulation. Although a net proinflammatory activity ascribed to interleukin-1beta was detected in ascites, a net antiinflammatory activity was measured in virtually all lymph and blood samples, suggesting that the pancreas and the splanchnic area are sites of a proinflammatory response and that an early, dominant, and sustained antiinflammatory activity takes place in circulating compartments.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1073-449X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
168
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
148-57
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12851244-Ascitic Fluid,
pubmed-meshheading:12851244-Biological Assay,
pubmed-meshheading:12851244-Cytokines,
pubmed-meshheading:12851244-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12851244-Female,
pubmed-meshheading:12851244-Humans,
pubmed-meshheading:12851244-Immunoenzyme Techniques,
pubmed-meshheading:12851244-Inflammation Mediators,
pubmed-meshheading:12851244-Lymph,
pubmed-meshheading:12851244-Male,
pubmed-meshheading:12851244-Middle Aged,
pubmed-meshheading:12851244-Multiple Organ Failure,
pubmed-meshheading:12851244-Pancreatitis, Acute Necrotizing,
pubmed-meshheading:12851244-Splanchnic Circulation,
pubmed-meshheading:12851244-Systemic Inflammatory Response Syndrome
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| pubmed:year |
2003
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| pubmed:articleTitle |
Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications.
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| pubmed:affiliation |
Department of Intensive Care and Emergency Medicine, St. Luc University Hospital, Hippocrate Avenue, 10 B-1200 Brussels, Belgium. thierry.dugernier@skynet.be
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| pubmed:publicationType |
Journal Article
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