Source:http://linkedlifedata.com/resource/pubmed/id/12837292
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-7-2
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| pubmed:abstractText |
PTPRQ (rPTP-GMC1) is a member of the type III receptor-like protein tyrosine phosphatase family. PTPRQ has very low activity against phosphotyrosine but is active against phosphatidylinositol phosphates that are involved in regulation of survival, proliferation, and subcellular architecture. Here, we report that PTPRQ can be expressed as a cytosolic or a receptor-like protein and that the form, subcellular localization, and cell types in which it is expressed are regulated by alternative promoter use and by alternative splicing. The first promoter drives expression of transcripts encoding a transmembrane protein in human podocytes and lung. PTPRQ protein is localized to the basal membrane of human podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney. A second promoter drives expression of a transcript that can encode a cytoplasmic protein containing the catalytic site. This is the major PTPRQ transcript in rat mesangial cells and human testis and is upregulated in mesangial cells in a rat model of mesangial proliferative glomerulonephritis. Differential regulation of expression of the transmembrane vs cytosolic forms, in different cell types during development or response to injury, may be a mechanism through which PTPRQ, with its activities against membrane phospholipids and against phosphotyrosine, can target specific substrates under different conditions.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptprq protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Like Protein Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0014-4827
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
287
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
374-86
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12837292-Adult,
pubmed-meshheading:12837292-Amino Acid Sequence,
pubmed-meshheading:12837292-Animals,
pubmed-meshheading:12837292-COS Cells,
pubmed-meshheading:12837292-Cell Line,
pubmed-meshheading:12837292-Cytosol,
pubmed-meshheading:12837292-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12837292-Humans,
pubmed-meshheading:12837292-Kidney,
pubmed-meshheading:12837292-Male,
pubmed-meshheading:12837292-Mice,
pubmed-meshheading:12837292-Muscle, Smooth,
pubmed-meshheading:12837292-Phosphatidylinositol Phosphates,
pubmed-meshheading:12837292-Protein Tyrosine Phosphatases,
pubmed-meshheading:12837292-RNA, Messenger,
pubmed-meshheading:12837292-Rats,
pubmed-meshheading:12837292-Rats, Sprague-Dawley,
pubmed-meshheading:12837292-Rats, Wistar,
pubmed-meshheading:12837292-Receptor-Like Protein Tyrosine Phosphatases, Class 3,
pubmed-meshheading:12837292-Receptors, Cell Surface,
pubmed-meshheading:12837292-Species Specificity,
pubmed-meshheading:12837292-Transcription, Genetic
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| pubmed:year |
2003
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| pubmed:articleTitle |
PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein.
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| pubmed:affiliation |
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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