Linked Life Data

12834913

Source:http://linkedlifedata.com/resource/pubmed/id/12834913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-7-1
pubmed:abstractText
Very little is known about the impact of selective estrogen receptor modulators (SERMs) on the brain. We examined the effects of tamoxifen (TAMOX) and the synthetic estrogen 17alpha-ethynylestradiol (EE) on estrogen-dependent gene expression and receptor binding in the female rat brain. Both immediate and residual effects were examined in both the presence and absence of 17beta-estradiol. Two groups of adult, ovariectomized, female rats (n=30 per group) were injected with TAMOX (5 mg/kg), EE (0.1 mg/kg), or sesame oil daily for 14 days. Animals from the first group were implanted with blank or 17beta-estradiol Silastic capsules concurrently with the last three SERM injections (immediate, group 1). Animals from the second group received either blank or 17beta-estradiol implants 2 weeks after the last injection (residual, group 2). All animals were sacrificed 72 h after implantation. TAMOX increased uterine weight in the absence of estrogen, but inhibited uterine weight gain in the presence of estrogen in both groups 1 and 2. TAMOX and EE increased oxytocin receptor binding in the ventromedial nucleus of the hypothalamus (VMN) in the absence of estrogen in both groups 1 and 2. The estrogen-dependent induction of PR mRNA expression in the VMN was significantly attenuated by TAMOX in group 1. Finally, TAMOX and EE had opposite effects on ERbeta mRNA expression in the paraventricular nucleus in the absence of 17beta-estradiol in group 1. Neither had any effect in group 2 when 17beta-estradiol was present. These results suggest that TAMOX has mixed agonist/antagonist effects in the female rat brain, many of which persist at least 2 weeks after the administration ceases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
978
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12834913-Animals, pubmed-meshheading:12834913-Autoradiography, pubmed-meshheading:12834913-Binding Sites, pubmed-meshheading:12834913-Drug Administration Schedule, pubmed-meshheading:12834913-Estradiol Congeners, pubmed-meshheading:12834913-Estrogen Antagonists, pubmed-meshheading:12834913-Ethinyl Estradiol, pubmed-meshheading:12834913-Fallopian Tubes, pubmed-meshheading:12834913-Female, pubmed-meshheading:12834913-Gene Expression Regulation, pubmed-meshheading:12834913-Hypothalamus, pubmed-meshheading:12834913-In Situ Hybridization, pubmed-meshheading:12834913-Organ Size, pubmed-meshheading:12834913-RNA, Messenger, pubmed-meshheading:12834913-Rats, pubmed-meshheading:12834913-Rats, Sprague-Dawley, pubmed-meshheading:12834913-Receptors, Oxytocin, pubmed-meshheading:12834913-Receptors, Progesterone, pubmed-meshheading:12834913-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12834913-Tamoxifen, pubmed-meshheading:12834913-Time Factors, pubmed-meshheading:12834913-Vasotocin
pubmed:year
2003
pubmed:articleTitle
Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus.
pubmed:affiliation
NSF Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA. hbeaupr@emory.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.