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rdf:type |
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lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0026809,
umls-concept:C0085358,
umls-concept:C0392762,
umls-concept:C0443252,
umls-concept:C0445356,
umls-concept:C0450254,
umls-concept:C0805586,
umls-concept:C0936012,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
14
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pubmed:dateCreated |
2003-6-27
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pubmed:abstractText |
The consequences for the long-term maintenance of virus-specific CD8+-T-cell memory have been analyzed experimentally for sequential respiratory infections with readily eliminated (influenza virus) and persistent (gammaherpesvirus 68 [gammaHV68]) pathogens. Sampling a broad range of tissue sites established that the numbers of CD8+ T cells specific for the prominent influenza virus D(b)NP(366) epitope were reduced by about half in mice that had been challenged 100 days previously with gammaHV68, though the prior presence of a large CD8+ D(b)NP366+ population caused no selective defect in the gammaHV68-specific CD8+ K(b)p79+ response. Conversely, mice that had been primed and boosted to generate substantial gammaHV68-specific CD8+ D(b)p56+ populations did not show any decrease in prevalence for this set of CD8+ memory cytotoxic T lymphocytes (CTL) at 200 days after respiratory exposure to an influenza A virus. However, in both experiments, the total magnitude of the CD8+-T-cell pool was significantly diminished in those that had been infected with gammaHV68 and the influenza A virus. The broader implications of these findings, especially under conditions of repeated exposure to unrelated pathogens, are explored with a mathematical model which emphasizes that the immune effector and memory "phenome" is a function of the overall infection experience of the individual.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10229071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10411921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10430934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10448140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10458986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10626895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10694575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10729142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10772974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-10837069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11090168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11287596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11342616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11344265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11390598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11447050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-11462049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-1534240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-1692070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-5309489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-7751644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-8586837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-8705861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-8782700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9064346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9151901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9405265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9491999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9565629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9620680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12829815-9655482
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7756-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12829815-Animals,
pubmed-meshheading:12829815-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12829815-Female,
pubmed-meshheading:12829815-Gammaherpesvirinae,
pubmed-meshheading:12829815-Herpesviridae Infections,
pubmed-meshheading:12829815-Immunologic Memory,
pubmed-meshheading:12829815-Influenza A virus,
pubmed-meshheading:12829815-Lymphocyte Activation,
pubmed-meshheading:12829815-Mice,
pubmed-meshheading:12829815-Mice, Inbred C57BL,
pubmed-meshheading:12829815-Models, Immunological,
pubmed-meshheading:12829815-Orthomyxoviridae Infections,
pubmed-meshheading:12829815-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Quantitative analysis of long-term virus-specific CD8+-T-cell memory in mice challenged with unrelated pathogens.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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