Linked Life Data

12824771

Source:http://linkedlifedata.com/resource/pubmed/id/12824771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-6-25
pubmed:abstractText
In this study we have examined the migration and phenotypic differentiation of human expanded neural precursors (hENPs) when transplanted into the intact adult rat brain. Primary human embryonic cortical cells and hENPs derived from the same source but expanded epigenetically in culture for two different time periods were transplanted into the rodent striatum and hippocampus. Histological analysis showed that overall the number of neurons decreased with time spent in culture prior to transplantation within the core of the graft regardless of site of implantation. Furthermore, transplanted cells migrated away from the graft to a similar extent irrespective of time in culture and site of implantation, although significantly more migrated cells were of a neuronal phenotype following transplantation into the hippocampus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1257-62
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Migration and differentiation of transplanted human neural precursor cells.
pubmed:affiliation
Cambridge University Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, UK. mj207@cam.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't