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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-6-24
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pubmed:abstractText |
A 656-bp PCR fragment from rpoB was sequenced from five rifampin-resistant Chlamydia trachomatis variants selected in vitro from a wild-type parent with a surprising level of genetic variability in this region. Three variants (MIC, 4 microg/ml) showed Ala522-->Val in cluster I (codons 507 to 533), which harbors mutations in most rifampin-resistant bacteria. Two high-level resistance variants (MICs, 64 and 256 microg/ml) showed His526-->Tyr in cluster I with additional genetic variation, some of which resulted in amino acid substitutions. None of the latter was situated in clusters related to rifampin resistance in other bacteria.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-10074552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-10508007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-10543773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-11083629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-11136757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-11290327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-11600348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-2552911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-3050121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-4583501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-638716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-712119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-7380772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-7840574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-8095569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-8257122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-8707747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-8849230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-8870258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-931365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12821487-9756760
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2316-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12821487-Antibiotics, Antitubercular,
pubmed-meshheading:12821487-Chlamydia trachomatis,
pubmed-meshheading:12821487-DNA-Directed RNA Polymerases,
pubmed-meshheading:12821487-Drug Resistance, Bacterial,
pubmed-meshheading:12821487-Genes, Bacterial,
pubmed-meshheading:12821487-Genetic Variation,
pubmed-meshheading:12821487-Mutation,
pubmed-meshheading:12821487-Rifampin
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pubmed:year |
2003
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pubmed:articleTitle |
Detection of nucleotide variability in rpoB in both rifampin-sensitive and rifampin-resistant strains of Chlamydia trachomatis.
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pubmed:affiliation |
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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