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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
37
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pubmed:dateCreated |
2003-9-8
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pubmed:abstractText |
Natural products comprise a major source of small molecular weight angiogenesis inhibitors. We have used the transformed endothelial cell line SVR as an effective screen of natural product extracts to isolate anti-angiogenesis and anti-tumor compounds. Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays. We found that the small molecular weight compound honokiol is the active principle of magnolia extract. Honokiol exhibited potent anti-proliferative activity against SVR cells in vitro. In addition, honokiol demonstrated preferential inhibition of primary human endothelial cells compared with fibroblasts and this inhibition was antagonized by antibodies against TNF alpha-related apoptosis-inducing ligand. In vivo, honokiol was highly effective against angiosarcoma in nude mice. Our preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:ArbiserJack LJL,
pubmed-author:BaiXianheX,
pubmed-author:BattleTraciT,
pubmed-author:CampbellPaul MPM,
pubmed-author:CerimeleFrancescaF,
pubmed-author:DerChanning JCJ,
pubmed-author:DubielWolfgangW,
pubmed-author:FranzDavid RDR,
pubmed-author:GovindarajanBaskaranB,
pubmed-author:MuradEmmaE,
pubmed-author:SoffGeraldG,
pubmed-author:Ushio-FukaiMasukoM,
pubmed-author:WaqasMuhammadM,
pubmed-author:YeKeqiangK
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35501-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12816951-Angiogenesis Inhibitors,
pubmed-meshheading:12816951-Animals,
pubmed-meshheading:12816951-Apoptosis,
pubmed-meshheading:12816951-Biphenyl Compounds,
pubmed-meshheading:12816951-Cell Division,
pubmed-meshheading:12816951-Cell Line,
pubmed-meshheading:12816951-Cell Line, Transformed,
pubmed-meshheading:12816951-Endothelium, Vascular,
pubmed-meshheading:12816951-Hemangiosarcoma,
pubmed-meshheading:12816951-Humans,
pubmed-meshheading:12816951-Lignans,
pubmed-meshheading:12816951-MAP Kinase Signaling System,
pubmed-meshheading:12816951-Magnolia,
pubmed-meshheading:12816951-Mice,
pubmed-meshheading:12816951-Mice, Nude,
pubmed-meshheading:12816951-Phytotherapy,
pubmed-meshheading:12816951-Plant Extracts,
pubmed-meshheading:12816951-Transplantation, Heterologous
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pubmed:year |
2003
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pubmed:articleTitle |
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
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pubmed:affiliation |
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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