| pubmed-article:12812997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C0042034 | lld:lifeskim |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C0040610 | lld:lifeskim |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C0234422 | lld:lifeskim |
| pubmed-article:12812997 | lifeskim:mentions | umls-concept:C1879743 | lld:lifeskim |
| pubmed-article:12812997 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12812997 | pubmed:dateCreated | 2003-6-18 | lld:pubmed |
| pubmed-article:12812997 | pubmed:abstractText | 1 (+/-)-Tramadol, a widely used analgesic, is a racemate stimulating opioid receptors and inhibiting reuptake of noradrenaline and serotonin, that is, pharmacological principles previously shown to influence rat micturition. 2 We studied both (+/-)-tramadol and its enantiomers in conscious Sprague-Dawley rats undergoing continuous cystometry. The effects of these agents were compared to those of morphine ( micro -opioid receptor agonist) and tested after pretreatment with naloxone ( micro -opioid receptor antagonist). Cystometries were evaluated before and after intravenous (i.v.), intraperitoneal (i.p.) and intrathecal (i.t.) drug administrations. 3 The most conspicuous effects of i.v. (+/-)-tramadol (0.1-10 mg kg(-1)) was an increase in threshold pressure and an increase in micturition volume. 4 These effects were mimicked by (+)-tramadol (0.1-5 mg kg(-1) i.v.), whereas (-)-tramadol (5 mg kg(-1) i.v.) did not influence threshold pressure and micturition volume. 5 The effects of (+/-)-tramadol 5 mg kg(-1) on micturition volume were blocked by pretreatment with naloxone 0.3 mg kg(-1). Morphine (0.3-10 mg kg(-1) i.p.) increased threshold pressure but did not significantly increase micturition volume in doses not resulting in overflow incontinence. 6 (+/-)-Tramadol 10 mg kg(-1) increased urine production, an effect blocked by desmopressin 25 ng kg(-1). 7 (+/-)-Tramadol effectively inhibits micturition in conscious rats by stimulating micro -opioid receptors. A synergy between opioid receptor stimulation and monoamine reuptake inhibition may contribute to the micturition effects. | lld:pubmed |
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| pubmed-article:12812997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12812997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12812997 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12812997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12812997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12812997 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12812997 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:12812997 | pubmed:author | pubmed-author:AnderssonKarl... | lld:pubmed |
| pubmed-article:12812997 | pubmed:author | pubmed-author:FriderichsElm... | lld:pubmed |
| pubmed-article:12812997 | pubmed:author | pubmed-author:ChristophThom... | lld:pubmed |
| pubmed-article:12812997 | pubmed:author | pubmed-author:PehrsonRikard... | lld:pubmed |
| pubmed-article:12812997 | pubmed:author | pubmed-author:PanditaRaj... | lld:pubmed |
| pubmed-article:12812997 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12812997 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:12812997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12812997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12812997 | pubmed:pagination | 741-8 | lld:pubmed |
| pubmed-article:12812997 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12812997 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12812997 | pubmed:articleTitle | Actions of tramadol on micturition in awake, freely moving rats. | lld:pubmed |
| pubmed-article:12812997 | pubmed:affiliation | Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden. Grünenthal GmbH, Aachen, Germany. | lld:pubmed |
| pubmed-article:12812997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12812997 | pubmed:publicationType | Comparative Study | lld:pubmed |
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