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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-6-18
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pubmed:abstractText |
1 (+/-)-Tramadol, a widely used analgesic, is a racemate stimulating opioid receptors and inhibiting reuptake of noradrenaline and serotonin, that is, pharmacological principles previously shown to influence rat micturition. 2 We studied both (+/-)-tramadol and its enantiomers in conscious Sprague-Dawley rats undergoing continuous cystometry. The effects of these agents were compared to those of morphine ( micro -opioid receptor agonist) and tested after pretreatment with naloxone ( micro -opioid receptor antagonist). Cystometries were evaluated before and after intravenous (i.v.), intraperitoneal (i.p.) and intrathecal (i.t.) drug administrations. 3 The most conspicuous effects of i.v. (+/-)-tramadol (0.1-10 mg kg(-1)) was an increase in threshold pressure and an increase in micturition volume. 4 These effects were mimicked by (+)-tramadol (0.1-5 mg kg(-1) i.v.), whereas (-)-tramadol (5 mg kg(-1) i.v.) did not influence threshold pressure and micturition volume. 5 The effects of (+/-)-tramadol 5 mg kg(-1) on micturition volume were blocked by pretreatment with naloxone 0.3 mg kg(-1). Morphine (0.3-10 mg kg(-1) i.p.) increased threshold pressure but did not significantly increase micturition volume in doses not resulting in overflow incontinence. 6 (+/-)-Tramadol 10 mg kg(-1) increased urine production, an effect blocked by desmopressin 25 ng kg(-1). 7 (+/-)-Tramadol effectively inhibits micturition in conscious rats by stimulating micro -opioid receptors. A synergy between opioid receptor stimulation and monoamine reuptake inhibition may contribute to the micturition effects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12812997-10454502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12812997-11015314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12812997-11261592,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
741-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12812997-Animals,
pubmed-meshheading:12812997-Deamino Arginine Vasopressin,
pubmed-meshheading:12812997-Drug Administration Routes,
pubmed-meshheading:12812997-Female,
pubmed-meshheading:12812997-Morphine,
pubmed-meshheading:12812997-Movement,
pubmed-meshheading:12812997-Naloxone,
pubmed-meshheading:12812997-Rats,
pubmed-meshheading:12812997-Rats, Inbred Strains,
pubmed-meshheading:12812997-Rats, Sprague-Dawley,
pubmed-meshheading:12812997-Receptors, Opioid, mu,
pubmed-meshheading:12812997-Stereoisomerism,
pubmed-meshheading:12812997-Tramadol,
pubmed-meshheading:12812997-Urinary Bladder,
pubmed-meshheading:12812997-Urination,
pubmed-meshheading:12812997-Urine,
pubmed-meshheading:12812997-Urodynamics
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pubmed:year |
2003
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pubmed:articleTitle |
Actions of tramadol on micturition in awake, freely moving rats.
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pubmed:affiliation |
Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden. Grünenthal GmbH, Aachen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study
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