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rdf:type |
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lifeskim:mentions |
umls-concept:C0015780,
umls-concept:C0023607,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0205099,
umls-concept:C0391871,
umls-concept:C0671870,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
7
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pubmed:dateCreated |
2003-6-17
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pubmed:abstractText |
Orexin A stimulates GnRH release from hypothalamic explants in vitro. The sites of action of orexin A in the regulation of LH release have been investigated in vivo in ovariectomized rats that were given vehicle or estradiol benzoate (EB), with or without an injection of progesterone 48 h later. Orexin A was administered intrahypothalamically under Saffan anesthesia, 50 h after the EB or vehicle; its effects on plasma LH levels were monitored in sequential blood samples. Orexin A (1.0 microg/side) injected into the rostral preoptic area (rPOA) at the level of the organum vasculosum of the lamina terminalis had a stimulatory effect on LH release in EB-treated ovariectomized rats. When orexin A was injected into the medial POA (mPOA) or the arcuate/median eminence, it had an inhibitory effect on the LH surge that occurs in ovariectomized rats primed with EB plus progesterone. Orexin A injected into the mPOA also reduced LH levels in ovariectomized rats untreated with ovarian steroids. Both the stimulatory and inhibitory effects of orexin A were antagonized by SB334867A, a selective orexin 1 receptor antagonist. Furthermore, when given alone into the rPOA, this antagonist attenuated the LH surge induced by EB plus progesterone. Thus, orexin appears to have a dual effect on LH release, being stimulatory in the rPOA and inhibitory in the mPOA or arcuate/median eminence. Both effects may be mediated, at least in part, by the orexin 1 receptor. Double label immunohistochemistry revealed close appositions between orexin A immunoreactive varicosities and a small proportion of GnRH cell bodies in the rPOA. It is suggested that the stimulatory effect of orexin A on LH release may involve direct actions on GnRH neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(2-methylbenzoxazol-6-yl)-3-(1,5)n...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Urea,
http://linkedlifedata.com/resource/pubmed/chemical/estradiol 3-benzoate,
http://linkedlifedata.com/resource/pubmed/chemical/orexin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0013-7227
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pubmed:author |
pubmed-author:BloomS RSR,
pubmed-author:GistD HDH,
pubmed-author:GoubillonM-LML,
pubmed-author:GrimshawS ESE,
pubmed-author:KalamatianosTT,
pubmed-author:KennedyA RAR,
pubmed-author:MurrayJ FJF,
pubmed-author:SiddiquiAA,
pubmed-author:SivanesanVV,
pubmed-author:SmallC JCJ,
pubmed-author:WilsonC ACA,
pubmed-author:YoungHH
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3225-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12810579-Animals,
pubmed-meshheading:12810579-Benzoxazoles,
pubmed-meshheading:12810579-Carrier Proteins,
pubmed-meshheading:12810579-Cells, Cultured,
pubmed-meshheading:12810579-Estradiol,
pubmed-meshheading:12810579-Female,
pubmed-meshheading:12810579-Gonadotropin-Releasing Hormone,
pubmed-meshheading:12810579-Immunohistochemistry,
pubmed-meshheading:12810579-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12810579-Luteinizing Hormone,
pubmed-meshheading:12810579-Microinjections,
pubmed-meshheading:12810579-Neuropeptides,
pubmed-meshheading:12810579-Ovariectomy,
pubmed-meshheading:12810579-Preoptic Area,
pubmed-meshheading:12810579-Progesterone,
pubmed-meshheading:12810579-Rats,
pubmed-meshheading:12810579-Rats, Wistar,
pubmed-meshheading:12810579-Receptors, G-Protein-Coupled,
pubmed-meshheading:12810579-Receptors, Neuropeptide,
pubmed-meshheading:12810579-Urea
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pubmed:year |
2003
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pubmed:articleTitle |
Central orexin A has site-specific effects on luteinizing hormone release in female rats.
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pubmed:affiliation |
Department of Obstetrics, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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