Different expression patterns of Bcl-2, Bcl-xl, and Bax proteins after sublethal forebrain ischemia in C57Black/Crj6 mouse striatum.

Source:http://linkedlifedata.com/resource/pubmed/id/12791942

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Authors

Hnat R, Qi S, Wu C, Fujihara H, Shimoji K, Baba H, Li H

Affiliation

Department of Anesthesiology, Niigata University School of Medicine, Japan. wcrmail@med.niigata-u.ac.jp

Abstract

Ischemic injury in neurons can be strongly reduced by a preceding sublethal ischemic episode, of which the mechanism is poorly understood. Although changes in the expression of apoptosis-related proteins (Bcl-2, Bcl-xl, and Bax) have been considered to be crucially important in ischemic injury, the roles these proteins play in ischemic preconditioning induced by sublethal forebrain ischemia have not been elucidated. Therefore, we investigated the transcription and expression of Bcl-2, Bcl-xl, and Bax in striatum of mice subjected to sublethal forebrain ischemia and lethal ischemia, with or without ischemic preconditioning.

PMID
12791942