| pubmed-article:12788472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0030012 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12788472 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12788472 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12788472 | pubmed:dateCreated | 2003-6-5 | lld:pubmed |
| pubmed-article:12788472 | pubmed:abstractText | The human oncogene bcl-2 exerts protective functions in numerous models of apoptotic cell death and increased oxidative stress. We investigated the effects of inducible bcl-2 overexpression on cellular survival and redox status in dopaminergic rat pheochromocytoma PC 12 cells. Induction of high-level expression of bcl-2 in PC 12 cells resulted in generation of oxidative stress and cessation of growth by cell cycle arrest. Cell cycle arrest in bcl-2-overexpressing PC 12 cells was prevented by an inhibitor of extracellular signal-related kinase (ERK 1/2) activation. Protective effects of bcl-2 expression against L-DOPA neurotoxicity decreased with increasing amounts of bcl-2. Furthermore, high-level bcl-2 overexpression sensitized cells towards oxidative stress and glutathione depletion. Our data suggest that bcl-2 expression is beneficial only in a limited gene dosage range and that high-level expression of bcl-2 exerts potential deleterious effects. | lld:pubmed |
| pubmed-article:12788472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12788472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12788472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12788472 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12788472 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:SchulzJörg... | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:KlockgetherTh... | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:SeyfriedJanJ | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:EvertBernd... | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:WüllnerUllric... | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:SchwarzCordel... | lld:pubmed |
| pubmed-article:12788472 | pubmed:author | pubmed-author:SchauppMatthi... | lld:pubmed |
| pubmed-article:12788472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12788472 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12788472 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:12788472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12788472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12788472 | pubmed:pagination | 1517-30 | lld:pubmed |
| pubmed-article:12788472 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
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| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
| pubmed-article:12788472 | pubmed:meshHeading | pubmed-meshheading:12788472... | lld:pubmed |
| pubmed-article:12788472 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12788472 | pubmed:articleTitle | Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status. | lld:pubmed |
| pubmed-article:12788472 | pubmed:affiliation | Department of Neurology, University of Bonn, Bonn, Germany. jan.seyfried@man.ac.uk | lld:pubmed |
| pubmed-article:12788472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12788472 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12788472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
