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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2003-6-3
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pubmed:databankReference |
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pubmed:abstractText |
A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC-12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC-12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so-called PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
544
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12782293-3T3 Cells,
pubmed-meshheading:12782293-Amino Acid Sequence,
pubmed-meshheading:12782293-Animals,
pubmed-meshheading:12782293-Blotting, Northern,
pubmed-meshheading:12782293-Blotting, Western,
pubmed-meshheading:12782293-Cell Cycle,
pubmed-meshheading:12782293-Cloning, Molecular,
pubmed-meshheading:12782293-Cytokines,
pubmed-meshheading:12782293-Cytoplasm,
pubmed-meshheading:12782293-DNA, Complementary,
pubmed-meshheading:12782293-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:12782293-Gene Library,
pubmed-meshheading:12782293-Immunohistochemistry,
pubmed-meshheading:12782293-Mice,
pubmed-meshheading:12782293-Molecular Sequence Data,
pubmed-meshheading:12782293-Nicotinamide Phosphoribosyltransferase,
pubmed-meshheading:12782293-PC12 Cells,
pubmed-meshheading:12782293-Rats,
pubmed-meshheading:12782293-Sequence Homology, Amino Acid,
pubmed-meshheading:12782293-Tissue Distribution,
pubmed-meshheading:12782293-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor.
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pubmed:affiliation |
Department of Biochemistry, Asahikawa Medical College, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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