| pubmed-article:12778465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0162351 | lld:lifeskim |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12778465 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:12778465 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12778465 | pubmed:dateCreated | 2003-6-2 | lld:pubmed |
| pubmed-article:12778465 | pubmed:abstractText | To determine whether macrophage migration inhibitory factor (MIF) is required for contact hypersensitivity (CHS) response, MIF-deficient (MIF KO) and wild-type (WT) mice were sensitized with trinitrochlorobenzene (TNCB) or oxazolone on their abdominal skin and challenged on the dorsum skin of one ear 5 days later. Significant ear swelling was observed in the WT mice, but this response was inhibited in the MIF KO mice (p<0.01 for MIF KO vs. WT mice in 24 h). In addition, lymph node cells from hapten-sensitized MIF KO mice showed a decreased capacity for transferring the CHS response. A topical application of TNCB (200 microg) caused a significant decline in epidermal Langerhans cell (LC) density (20.3%; p<0.01 compared with vehicle) 4 h after application in WT mice, but it failed to provoke a significant epidermal LC migration in MIF KO mice (7.4%). By mixed lymphocyte reaction, the T cell proliferative response to alloantigen was significantly decreased in the MIF KO mice compared with WT mice (p<0.005). Taken together, these results indicate that MIF is pivotal in the regulation of cutaneous immune responses and plays a central role in LC migration and T cell proliferation for the CHS response. | lld:pubmed |
| pubmed-article:12778465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12778465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778465 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12778465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12778465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12778465 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12778465 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:NakayamaToshi... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:TaniguchiMasa... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:NishihiraJunJ | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:ShimizuHirosh... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:ShimizuTadami... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:AbeRiichiroR | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:WatanabeHirok... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:IshibashiTeru... | lld:pubmed |
| pubmed-article:12778465 | pubmed:author | pubmed-author:ShibakiAkihik... | lld:pubmed |
| pubmed-article:12778465 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12778465 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12778465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12778465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12778465 | pubmed:pagination | 1478-87 | lld:pubmed |
| pubmed-article:12778465 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12778465 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12778465 | pubmed:articleTitle | Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice. | lld:pubmed |
| pubmed-article:12778465 | pubmed:affiliation | Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. | lld:pubmed |
| pubmed-article:12778465 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12778465 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17319 | entrezgene:pubmed | pubmed-article:12778465 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12778465 | lld:pubmed |
