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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-2
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pubmed:abstractText |
To determine whether macrophage migration inhibitory factor (MIF) is required for contact hypersensitivity (CHS) response, MIF-deficient (MIF KO) and wild-type (WT) mice were sensitized with trinitrochlorobenzene (TNCB) or oxazolone on their abdominal skin and challenged on the dorsum skin of one ear 5 days later. Significant ear swelling was observed in the WT mice, but this response was inhibited in the MIF KO mice (p<0.01 for MIF KO vs. WT mice in 24 h). In addition, lymph node cells from hapten-sensitized MIF KO mice showed a decreased capacity for transferring the CHS response. A topical application of TNCB (200 microg) caused a significant decline in epidermal Langerhans cell (LC) density (20.3%; p<0.01 compared with vehicle) 4 h after application in WT mice, but it failed to provoke a significant epidermal LC migration in MIF KO mice (7.4%). By mixed lymphocyte reaction, the T cell proliferative response to alloantigen was significantly decreased in the MIF KO mice compared with WT mice (p<0.005). Taken together, these results indicate that MIF is pivotal in the regulation of cutaneous immune responses and plays a central role in LC migration and T cell proliferation for the CHS response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1478-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12778465-Administration, Topical,
pubmed-meshheading:12778465-Adoptive Transfer,
pubmed-meshheading:12778465-Animals,
pubmed-meshheading:12778465-Chemotaxis, Leukocyte,
pubmed-meshheading:12778465-Croton Oil,
pubmed-meshheading:12778465-Dermatitis, Allergic Contact,
pubmed-meshheading:12778465-Edema,
pubmed-meshheading:12778465-Epidermis,
pubmed-meshheading:12778465-Female,
pubmed-meshheading:12778465-Haptens,
pubmed-meshheading:12778465-Immune Sera,
pubmed-meshheading:12778465-Immunoglobulin G,
pubmed-meshheading:12778465-Irritants,
pubmed-meshheading:12778465-Isoantigens,
pubmed-meshheading:12778465-Langerhans Cells,
pubmed-meshheading:12778465-Lymph Nodes,
pubmed-meshheading:12778465-Lymphocyte Activation,
pubmed-meshheading:12778465-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:12778465-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:12778465-Mice,
pubmed-meshheading:12778465-Mice, Inbred BALB C,
pubmed-meshheading:12778465-Mice, Inbred C57BL,
pubmed-meshheading:12778465-Mice, Knockout,
pubmed-meshheading:12778465-Oxazolone,
pubmed-meshheading:12778465-Picryl Chloride,
pubmed-meshheading:12778465-Rabbits,
pubmed-meshheading:12778465-Specific Pathogen-Free Organisms
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pubmed:year |
2003
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pubmed:articleTitle |
Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice.
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pubmed:affiliation |
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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