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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-5-26
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pubmed:abstractText |
Upon incubation of human red blood cells (RBC) with [4-9-14C] N-acetylneuraminic acid, the cells incorporated this sugar, as demonstrated by the identification of labelled N-acetylmannosamine in the cytosol, as a result of the action of the sialic acid pyruvate-lyase we discovered previously (Biochimie 84 (2002) 655). The mechanism is saturable and indicates the presence of a limited number of transporter molecules in the RBC membrane. This transport process may have relevance to the desialylation of membrane glycoconjugates which occurs during ageing of erythrocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-9084
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12765793-Autoradiography,
pubmed-meshheading:12765793-Biological Transport,
pubmed-meshheading:12765793-Carbon Radioisotopes,
pubmed-meshheading:12765793-Chromatography, Thin Layer,
pubmed-meshheading:12765793-Cytosol,
pubmed-meshheading:12765793-Erythrocytes,
pubmed-meshheading:12765793-Humans,
pubmed-meshheading:12765793-N-Acetylneuraminic Acid,
pubmed-meshheading:12765793-Organic Anion Transporters,
pubmed-meshheading:12765793-Oxo-Acid-Lyases,
pubmed-meshheading:12765793-Sialic Acids,
pubmed-meshheading:12765793-Symporters
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pubmed:articleTitle |
Uptake of sialic acid by human erythrocyte. Characterization of a transport system.
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pubmed:affiliation |
Facultatea de Biologie, Laboratorul de Biochimie, Universitatea Alexandru Ioan Cuza, Bd-ul Copou nr.11, 6600 Iasi-6, Romania.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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