Linked Life Data

12754995

Source:http://linkedlifedata.com/resource/pubmed/id/12754995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-20
pubmed:abstractText
Compared with the mechanisms of adaptive responses of the heart, the mechanisms of maladaptation have been less elucidated. However, the followings are probably responsible for the progression of heart failure: 1) progressive loss of cardiac myocytes (quantity change); 2) progression of systolic dysfunction of individual myocytes(quality change); or 3) both. Apoptosis may be responsible for the myocyte death although controversial. Myocytes of failing hearts shows dramatic phenotype alterations in the structure, function, and biochemical events such as fetal type gene induction. Hypertrophy and degeneration of myocytes are the common, but not specific, features in failing hearts. Meanwhile, not only myocyte phenotype alterations but also myocardial interstitial changes such as extracellular matrix deposition, activation of fibroblasts, and narrowing of vessel lumens play important roles for the progression of heart failure.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
731-8
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Phenotype alterations of failing myocardium].
pubmed:affiliation
Second Department of Internal Medicine, Gifu University School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review