| pubmed-article:12754175 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0059563 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0005823 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C1413882 | lld:lifeskim |
| pubmed-article:12754175 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:12754175 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12754175 | pubmed:dateCreated | 2003-8-11 | lld:pubmed |
| pubmed-article:12754175 | pubmed:abstractText | A single-nucleotide polymorphism (A6986G) in the cytochrome p-450 3A5 (CYP3A5) gene distinguishes an expressor (*1) and a reduced-expressor (*3) allele and largely predicts CYP3A5 content in liver and intestine. CYP3A5 is the prevailing CYP3A isoform in kidney. We report that, among renal microsomes from 21 organ donors, those from *1/*3 individuals had at least eightfold higher mean kidney microsomal CYP3A5 content and 18-fold higher mean CYP3A catalytic activity than did those from *3/*3 individuals (P = 0.0001 and P = 0.0137, respectively). We also report significant associations between the A6986G polymorphism and systolic blood pressure (P = 0.0007), mean arterial pressure (P = 0.0075), and creatinine clearance (P = 0.0035) among 25 healthy African-American adults. These associations remained significant when sex, age, and body mass index were taken into account. The mean systolic blood pressure of homozygous CYP3A5 expressors (*1/*1) exceeded that of homozygous nonexpressors (*3/*3) by 19.3 mmHg. We speculate whether a high CYP3A5 expressor allele frequency among African-Americans may contribute to a high prevalence of sodium-sensitive hypertension in this population. | lld:pubmed |
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| pubmed-article:12754175 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12754175 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12754175 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12754175 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12754175 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12754175 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:DowlingAmy... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:LambaJatinder... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:LinYvonne SYS | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:WatkinsPaul... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:SchuetzErin... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:ThummelKennet... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:StewartPaul... | lld:pubmed |
| pubmed-article:12754175 | pubmed:author | pubmed-author:GivensRaymond... | lld:pubmed |
| pubmed-article:12754175 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12754175 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:12754175 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12754175 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12754175 | pubmed:pagination | 1297-300 | lld:pubmed |
| pubmed-article:12754175 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12754175 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12754175 | pubmed:articleTitle | CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. | lld:pubmed |
| pubmed-article:12754175 | pubmed:affiliation | General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA. | lld:pubmed |
| pubmed-article:12754175 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12754175 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12754175 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12754175 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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