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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-8-11
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pubmed:abstractText |
A single-nucleotide polymorphism (A6986G) in the cytochrome p-450 3A5 (CYP3A5) gene distinguishes an expressor (*1) and a reduced-expressor (*3) allele and largely predicts CYP3A5 content in liver and intestine. CYP3A5 is the prevailing CYP3A isoform in kidney. We report that, among renal microsomes from 21 organ donors, those from *1/*3 individuals had at least eightfold higher mean kidney microsomal CYP3A5 content and 18-fold higher mean CYP3A catalytic activity than did those from *3/*3 individuals (P = 0.0001 and P = 0.0137, respectively). We also report significant associations between the A6986G polymorphism and systolic blood pressure (P = 0.0007), mean arterial pressure (P = 0.0075), and creatinine clearance (P = 0.0035) among 25 healthy African-American adults. These associations remained significant when sex, age, and body mass index were taken into account. The mean systolic blood pressure of homozygous CYP3A5 expressors (*1/*1) exceeded that of homozygous nonexpressors (*3/*3) by 19.3 mmHg. We speculate whether a high CYP3A5 expressor allele frequency among African-Americans may contribute to a high prevalence of sodium-sensitive hypertension in this population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1297-300
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12754175-Adolescent,
pubmed-meshheading:12754175-Adult,
pubmed-meshheading:12754175-African Continental Ancestry Group,
pubmed-meshheading:12754175-Alleles,
pubmed-meshheading:12754175-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:12754175-Blood Pressure,
pubmed-meshheading:12754175-Body Mass Index,
pubmed-meshheading:12754175-Creatinine,
pubmed-meshheading:12754175-Cytochrome P-450 CYP3A,
pubmed-meshheading:12754175-Cytochrome P-450 Enzyme System,
pubmed-meshheading:12754175-European Continental Ancestry Group,
pubmed-meshheading:12754175-Gene Frequency,
pubmed-meshheading:12754175-Genotype,
pubmed-meshheading:12754175-Hispanic Americans,
pubmed-meshheading:12754175-Humans,
pubmed-meshheading:12754175-Isoenzymes,
pubmed-meshheading:12754175-Kidney,
pubmed-meshheading:12754175-Male,
pubmed-meshheading:12754175-Microsomes,
pubmed-meshheading:12754175-Middle Aged,
pubmed-meshheading:12754175-Oxidoreductases, N-Demethylating,
pubmed-meshheading:12754175-Polymorphism, Single Nucleotide,
pubmed-meshheading:12754175-Predictive Value of Tests
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pubmed:year |
2003
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pubmed:articleTitle |
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
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pubmed:affiliation |
General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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