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pubmed:abstractText |
A reduced capacity of antigen presenting cells (APC) to provide pro-T helper 1 (Th1) signals, such as IL-12, to T cells during early life may be implicated in the development of T helper 2 (Th2)-mediated allergic disease. In this study we examined the relationships between the capacity for IL-12 responses in the neonatal period and atopic risk (family allergy), in vitro T cell responses to allergens, and the subsequent development of allergic disease at 6 years.
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pubmed:affiliation |
Department of Paediatrics, Division of Clinical Sciences and Division of Cell Biology, School of Paediatrics and Child Health Research, University of Western Australia, and Princess Margaret Hospital, Perth, Australia. susanp@ichr.uwa.edu.au
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