Source:http://linkedlifedata.com/resource/pubmed/id/12747754
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2003-5-15
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| pubmed:abstractText |
Melanoma line LG2-MEL expresses several antigens recognized by autologous CTLs. One of them consists of a peptide derived from tyrosinase and presented by HLA-B*3503. We have identified another antigen of LG2-MEL as a peptide presented by HLA-B*4403 and resulting from a point mutation in gene OS-9. This gene is expressed in various normal tissues. It is located on chromosome 12 in the vicinity of the CDK4 locus and is frequently co-amplified with CDK4 in human sarcomas. The mutation, a C-to-T transition, changes a proline residue into a leucine at position 446 of the OS-9 protein. Mutated transcripts were found in all the melanoma sublines of LG2-MEL. None of the 184 tumor samples collected from other cancer patients expressed the mutated transcript, indicating that this is a rare mutational event. Interestingly, some of the melanoma sublines of LG2-MEL have lost the wild-type allele of gene OS-9. Those sublines appear to grow faster in vitro than the sublines that retained the wild-type allele, suggesting that this loss of heterozygosity may favor tumor progression. The mutation we have identified in gene OS-9 might therefore participate in the oncogenic process by affecting the function of this potential tumor-suppressor gene.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B44 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/OS9 protein, human
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1424-9634
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
19
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| pubmed:volume |
2
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12747754-Amino Acid Sequence,
pubmed-meshheading:12747754-Animals,
pubmed-meshheading:12747754-Antigens, Neoplasm,
pubmed-meshheading:12747754-Base Sequence,
pubmed-meshheading:12747754-COS Cells,
pubmed-meshheading:12747754-Clone Cells,
pubmed-meshheading:12747754-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:12747754-DNA, Complementary,
pubmed-meshheading:12747754-HLA-B Antigens,
pubmed-meshheading:12747754-HLA-B44 Antigen,
pubmed-meshheading:12747754-Humans,
pubmed-meshheading:12747754-Lectins,
pubmed-meshheading:12747754-Melanoma,
pubmed-meshheading:12747754-Molecular Sequence Data,
pubmed-meshheading:12747754-Neoplasm Proteins,
pubmed-meshheading:12747754-Point Mutation,
pubmed-meshheading:12747754-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12747754-Tumor Cells, Cultured
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| pubmed:year |
2002
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| pubmed:articleTitle |
Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma.
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| pubmed:affiliation |
Laboratory of Experimental Surgery, Tour de Pathologie, Université de Liège, Liège, Belgium.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|