rdf:type |
|
lifeskim:mentions |
umls-concept:C0007587,
umls-concept:C0017262,
umls-concept:C0087111,
umls-concept:C0205263,
umls-concept:C0245662,
umls-concept:C0253023,
umls-concept:C0376669,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1533691,
umls-concept:C1539477,
umls-concept:C2325187
|
pubmed:issue |
3
|
pubmed:dateCreated |
2003-5-15
|
pubmed:abstractText |
Despite advances in intraocular lens design and material, posterior capsule opacification remains one of the major problems in modern cataract surgery. Therefore, the use of antiproliferative agents has been advocated. CD95 ligand (CD95L, Fas, Apo-1) is a death ligand that triggers apoptosis in susceptible target cells. Apoptosis allows for the safe disposal of cells without damaging the surrounding tissue. The goal of this study was to characterize and evaluate CD95L-induced cell death in cultured lens epithelial cells (LEC).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1120-6721
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
241-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12747644-Animals,
pubmed-meshheading:12747644-Antigens, CD95,
pubmed-meshheading:12747644-Apoptosis,
pubmed-meshheading:12747644-Cells, Cultured,
pubmed-meshheading:12747644-Comet Assay,
pubmed-meshheading:12747644-DNA,
pubmed-meshheading:12747644-DNA Fragmentation,
pubmed-meshheading:12747644-Epithelial Cells,
pubmed-meshheading:12747644-Fas Ligand Protein,
pubmed-meshheading:12747644-Flow Cytometry,
pubmed-meshheading:12747644-Lens, Crystalline,
pubmed-meshheading:12747644-Ligands,
pubmed-meshheading:12747644-Membrane Glycoproteins,
pubmed-meshheading:12747644-Swine
|
pubmed:year |
2003
|
pubmed:articleTitle |
Lens epithelial cells express CD95 and CD95 ligand treatment induces cell death and DNA fragmentation in vitro.
|
pubmed:affiliation |
Center of Ophthalmology, University of Cologne, Cologne, Germany. Arno.Hueber@Uni-Koeln.de
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|