Linked Life Data

12742427

Source:http://linkedlifedata.com/resource/pubmed/id/12742427

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-13
pubmed:abstractText
Mixed acute cellular and humoral rejection is diagnosed uncommonly among heart transplant recipients and usually occurs within the first post-transplant month. We report a case of fatal, fulminant, mixed, acute cellular and humoral rejection in a 33-year-old woman 6 weeks after orthotopic heart transplantation. She had been treated with intravenous methylprednisolone for International Society for Heart and Lung Transplantation (ISHLT) Grade 2 rejection at post-operative Day 28. Despite intensification of immunosuppression therapy, she developed fever and progressive hemodynamic instability. Autopsy results revealed ISHLT Grade 4 mixed cellular and humoral rejection. Cellular rejection is a well-described mechanism of graft failure early after heart transplantation. Although humoral rejection also is recognized as contributing to early graft failure, its characteristics and clinical implications are not as well characterized. We describe a patient with fulminant mixed rejection, despite intensified immunosuppression therapy, early after orthotopic heart transplantation who presented with high-grade fever. We include a review of the literature on humoral and mixed rejections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1053-2498
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
604-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Fulminant mixed humoral and cellular rejection in a cardiac transplant recipient: a review of the histologic findings and literature.
pubmed:affiliation
Internal Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. wendy_book@emoryhealthcare.org
pubmed:publicationType
Journal Article, Review, Case Reports