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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-5-13
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pubmed:abstractText |
We have previously reported a monoclonal antibody (mAb), U5A2-13 mAb, which originally recognizes a phenotypically and functionally similar population of natural killer (NK)-like T cells. In this study, we found that U5A2-13 antigen (U5A2-13) was expressed not only on NK-like T cells but also on T and B cells during activation. In contrast to the low levels of U5A2-13 on freshly harvested T and B cells, the activation of these cells by various stimuli resulted in high levels of expression of U5A2-13 in vitro and in vivo. Similar to CD69, U5A2-13 is also expressed in most mouse lymphoid cell lines but not in nonhematopoietic cells. U5A2-13 on T cells reached maximal expression by 24h after stimulation and returned to baseline levels after 3 days. However, U5A2-13 differed from CD69 since its expression profile was different on CD4(+)- and CD8(+)-activated T cells, phorbol ester-activated EL-4 cells, and activated splenocytes in CD69-deficient mice. In addition, immunoprecipitation study indicated that U5A2-13 is not identical to CD69. Importantly, the U5A2-13-positive population of CD4(+) T cells exhibited significant levels of cytokine producing activity upon stimulation. Overall, U5A2-13 is an early inducible cell surface antigen that could be involved in lymphocyte activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
221
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-36
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12742379-Animals,
pubmed-meshheading:12742379-Antibodies, Monoclonal,
pubmed-meshheading:12742379-Antigens, CD,
pubmed-meshheading:12742379-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:12742379-Antigens, Surface,
pubmed-meshheading:12742379-B-Lymphocytes,
pubmed-meshheading:12742379-Cell Line,
pubmed-meshheading:12742379-Cells, Cultured,
pubmed-meshheading:12742379-Cytokines,
pubmed-meshheading:12742379-Female,
pubmed-meshheading:12742379-Killer Cells, Natural,
pubmed-meshheading:12742379-Kinetics,
pubmed-meshheading:12742379-Lectins, C-Type,
pubmed-meshheading:12742379-Lymphocyte Activation,
pubmed-meshheading:12742379-Mice,
pubmed-meshheading:12742379-Mice, Inbred C57BL,
pubmed-meshheading:12742379-Mice, Inbred MRL lpr,
pubmed-meshheading:12742379-Spleen,
pubmed-meshheading:12742379-T-Lymphocytes,
pubmed-meshheading:12742379-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
U5A2-13, an antigen originally found on mouse NK-like T cells, is an early inducible cell surface antigen during lymphoid activation.
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pubmed:affiliation |
Pharmacology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan. kakazu@sapmed.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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