Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-5-29
pubmed:abstractText
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. Here we show that cytotoxicity, but not cytokine production, is triggered by NKG2D in activated NK cells lacking either DAP12 or the Syk family members Syk and ZAP70. Inhibition of PI3K blocks this cytotoxicity, suggesting that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells. Our results highlight signaling divergence in the effector functions of NKG2D and indicate that alternative associations between a receptor and its adaptors may provide a single receptor with a dual 'on-switch', giving mouse NK cells more choices through which to trigger cytotoxicity.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell, http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase, http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase, http://linkedlifedata.com/resource/pubmed/chemical/Zap70 protein, mouse
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2908
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
565-72
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:12740576-Animals, pubmed-meshheading:12740576-Cytotoxicity, Immunologic, pubmed-meshheading:12740576-Enzyme Precursors, pubmed-meshheading:12740576-Female, pubmed-meshheading:12740576-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:12740576-Killer Cells, Natural, pubmed-meshheading:12740576-Male, pubmed-meshheading:12740576-Membrane Glycoproteins, pubmed-meshheading:12740576-Mice, pubmed-meshheading:12740576-Mice, Inbred C57BL, pubmed-meshheading:12740576-Mice, Knockout, pubmed-meshheading:12740576-NK Cell Lectin-Like Receptor Subfamily K, pubmed-meshheading:12740576-Neoplasms, Experimental, pubmed-meshheading:12740576-Phosphatidylinositol 3-Kinases, pubmed-meshheading:12740576-Protein-Tyrosine Kinases, pubmed-meshheading:12740576-Receptors, Immunologic, pubmed-meshheading:12740576-Receptors, Natural Killer Cell, pubmed-meshheading:12740576-Signal Transduction, pubmed-meshheading:12740576-Tumor Cells, Cultured, pubmed-meshheading:12740576-ZAP-70 Protein-Tyrosine Kinase
pubmed:year
2003
pubmed:articleTitle
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
pubmed:affiliation
Department of Immunology, Pasteur Institute, 25-28 rue Dr Roux, 75015 Paris, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't