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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-5-9
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pubmed:abstractText |
The natural anticoagulant-activated protein C may inhibit inflammation and fibrosis in the lung. Platelet-derived growth factor is involved in the pathogenesis of lung fibrosis. This study assessed the effect of activated protein C on platelet-derived growth factor expression in human cell lines and in an in vivo model of lung fibrosis. Activated protein C significantly inhibited the secretion and expression of platelet-derived growth factor in human lung cell lines, primary bronchial epithelial cells, and macrophages. In vitro studies also showed that the endothelial activated protein C receptor is expressed by lung epithelial cells and macrophages, and that this receptor and the proteolytic activity of activated protein are implicated in the inhibition of platelet-derived growth factor expression. In the in vivo model of lung fibrosis, intratracheal administration of activated protein C decreased the expression of platelet-derived growth factor and suppressed the development of lung fibrosis. Concomitant intratracheal administration of activated protein C and anti-endothelial activated protein C receptor or anti-platelet-derived growth factor suppressed the inhibitory activity of activated protein C in vivo. In brief, this study describes a novel biological function of activated protein C that may further explain its inhibitory activity on lung inflammation and fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1073-449X
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pubmed:author |
pubmed-author:AdachiYukihikoY,
pubmed-author:D'Alessandro-GabazzaCorina NCN,
pubmed-author:FukudomeKenjiK,
pubmed-author:GabazzaEsteban CEC,
pubmed-author:HayashiTatsuyaT,
pubmed-author:HommaIkuoI,
pubmed-author:IdoMasaruM,
pubmed-author:IwaseMichikoM,
pubmed-author:IzumizakiMasahikoM,
pubmed-author:KobayashiHiroshiH,
pubmed-author:NakagakiTomohiroT,
pubmed-author:ShimizuShinoS,
pubmed-author:ShimizuTakeshiT,
pubmed-author:SuzukiKojiK,
pubmed-author:TaguchiOsamuO,
pubmed-author:TaguchiYukikoY,
pubmed-author:TsuneyoshiNaokoN,
pubmed-author:YasuiHirokiH
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1416-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12738599-Analysis of Variance,
pubmed-meshheading:12738599-Animals,
pubmed-meshheading:12738599-Base Sequence,
pubmed-meshheading:12738599-Bleomycin,
pubmed-meshheading:12738599-Blood Coagulation Factors,
pubmed-meshheading:12738599-Blotting, Northern,
pubmed-meshheading:12738599-Cells, Cultured,
pubmed-meshheading:12738599-DNA, Complementary,
pubmed-meshheading:12738599-Disease Models, Animal,
pubmed-meshheading:12738599-Epithelial Cells,
pubmed-meshheading:12738599-Female,
pubmed-meshheading:12738599-Gene Expression Regulation,
pubmed-meshheading:12738599-Lung,
pubmed-meshheading:12738599-Mice,
pubmed-meshheading:12738599-Mice, Inbred C57BL,
pubmed-meshheading:12738599-Mice, Transgenic,
pubmed-meshheading:12738599-Molecular Sequence Data,
pubmed-meshheading:12738599-Platelet-Derived Growth Factor,
pubmed-meshheading:12738599-Probability,
pubmed-meshheading:12738599-Pulmonary Fibrosis,
pubmed-meshheading:12738599-Random Allocation,
pubmed-meshheading:12738599-Receptors, Cell Surface,
pubmed-meshheading:12738599-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12738599-Sensitivity and Specificity
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pubmed:year |
2003
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pubmed:articleTitle |
Activated protein C inhibits the expression of platelet-derived growth factor in the lung.
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pubmed:affiliation |
Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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