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pubmed-article:12730871pubmed:abstractTextThe TCF1 gene encoding hepatocyte nuclear factor 1 alpha (HNF1), a transcription factor germline mutated in patients with maturity-onset diabetes of the young type 3, was recently found to be frequently inactivated by biallelic alterations in liver adenoma and in rare hepatocellular carcinomas. The impact of HNF1 in colorectal carcinogenesis has not been studied until now. Colorectal cancer is characterized by the existence of different molecular mechanisms known as microsatellite stable or unstable tumors.lld:pubmed
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pubmed-article:12730871pubmed:articleTitleFrequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.lld:pubmed
pubmed-article:12730871pubmed:affiliationINSERM Unité 434, CEPH Fondation Jean Dausset, Paris. pierre.laurent-puig@biomedicale.univ-paris5.frlld:pubmed
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