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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-5
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pubmed:abstractText |
The TCF1 gene encoding hepatocyte nuclear factor 1 alpha (HNF1), a transcription factor germline mutated in patients with maturity-onset diabetes of the young type 3, was recently found to be frequently inactivated by biallelic alterations in liver adenoma and in rare hepatocellular carcinomas. The impact of HNF1 in colorectal carcinogenesis has not been studied until now. Colorectal cancer is characterized by the existence of different molecular mechanisms known as microsatellite stable or unstable tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1311-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12730871-Adenoma,
pubmed-meshheading:12730871-Aged,
pubmed-meshheading:12730871-Alleles,
pubmed-meshheading:12730871-Carcinoma,
pubmed-meshheading:12730871-Colorectal Neoplasms,
pubmed-meshheading:12730871-DNA-Binding Proteins,
pubmed-meshheading:12730871-Female,
pubmed-meshheading:12730871-Frameshift Mutation,
pubmed-meshheading:12730871-Genetic Predisposition to Disease,
pubmed-meshheading:12730871-Genetic Testing,
pubmed-meshheading:12730871-Hepatocyte Nuclear Factor 1,
pubmed-meshheading:12730871-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:12730871-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:12730871-Humans,
pubmed-meshheading:12730871-Male,
pubmed-meshheading:12730871-Microsatellite Repeats,
pubmed-meshheading:12730871-Middle Aged,
pubmed-meshheading:12730871-Nuclear Proteins,
pubmed-meshheading:12730871-Prevalence,
pubmed-meshheading:12730871-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.
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pubmed:affiliation |
INSERM Unité 434, CEPH Fondation Jean Dausset, Paris. pierre.laurent-puig@biomedicale.univ-paris5.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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