Source:http://linkedlifedata.com/resource/pubmed/id/12722167
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-4-30
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| pubmed:abstractText |
We studied effects on parkinsonian features at 6 and 12 months in 12 patients who underwent unilateral ablation of subthalamic nucleus (STN). Microelectrode mapping was used, and a lesion was created in the STN using thermal coagulation and confirmed with magnetic resonance imaging. At 6 months postoperatively, improvements were seen in several areas: 1) Unified Parkinson's Disease Rating Scales II and III (UPDRS II and III) scores, 30% in off period, 38% in on period; 2) Schwab and England Scale (S&E) score, 21%; and 3) on dyskinesia, 85%. Contralateral rigidity, bradykinesia, UPDRS II and III scores, and S&E scores remained improved at 12 months. Daily dosage of levodopa requirement was reduced by 42%. Axial motor features, gait, postural stability, off period tremor, and motor fluctuation improved at 6 and 12 months but showed a decline in benefits at 18 months. Complications include 3 cases of hemiballism, of whom 2 patients recovered spontaneously but 1 died from aspiration pneumonia. One patient had asymptomatic hematoma, and 2 suffered transient postural asymmetries. We conclude that unilateral subthalamotomy results in moderate improvement in all aspects of parkinsonian features, allows reduction in the dose of levodopa required, and ameliorates drug-induced complications throughout 12-month assessments.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0885-3185
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 Movement Disorder Society
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| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
531-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12722167-Adult,
pubmed-meshheading:12722167-Aged,
pubmed-meshheading:12722167-Antiparkinson Agents,
pubmed-meshheading:12722167-Dyskinesias,
pubmed-meshheading:12722167-Electrocoagulation,
pubmed-meshheading:12722167-Female,
pubmed-meshheading:12722167-Follow-Up Studies,
pubmed-meshheading:12722167-Humans,
pubmed-meshheading:12722167-Hypokinesia,
pubmed-meshheading:12722167-Levodopa,
pubmed-meshheading:12722167-Magnetic Resonance Imaging,
pubmed-meshheading:12722167-Male,
pubmed-meshheading:12722167-Microelectrodes,
pubmed-meshheading:12722167-Middle Aged,
pubmed-meshheading:12722167-Parkinson Disease,
pubmed-meshheading:12722167-Postoperative Complications,
pubmed-meshheading:12722167-Posture,
pubmed-meshheading:12722167-Questionnaires,
pubmed-meshheading:12722167-Severity of Illness Index,
pubmed-meshheading:12722167-Subthalamic Nucleus,
pubmed-meshheading:12722167-Time
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| pubmed:year |
2003
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| pubmed:articleTitle |
Treatment of advanced Parkinson's disease by subthalamotomy: one-year results.
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| pubmed:affiliation |
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, China. philipsu@ha.mc.ntu.edu.tw
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| pubmed:publicationType |
Journal Article
|