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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-4-30
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pubmed:abstractText |
With increasing age, the prevalence of osteoarthritis increases and the efficacy of articular cartilage repair decreases. As chondrocytes age, they synthesize smaller, less uniform aggrecan molecules and less functional link proteins, their mitotic and synthetic activity decline, and their responsiveness to anabolic mechanical stimuli and growth factors decreases. These observations led us to hypothesize that progressive cell senescence decreases the ability of chondrocytes to maintain and to restore articular cartilage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0021-9355
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85-A Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-10
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pubmed:dateRevised |
2010-10-25
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pubmed:meshHeading |
pubmed-meshheading:12721352-Adolescent,
pubmed-meshheading:12721352-Adult,
pubmed-meshheading:12721352-Aged,
pubmed-meshheading:12721352-Aged, 80 and over,
pubmed-meshheading:12721352-Aging,
pubmed-meshheading:12721352-Cartilage, Articular,
pubmed-meshheading:12721352-Cell Aging,
pubmed-meshheading:12721352-Cells, Cultured,
pubmed-meshheading:12721352-Child,
pubmed-meshheading:12721352-Child, Preschool,
pubmed-meshheading:12721352-Chondrocytes,
pubmed-meshheading:12721352-Humans,
pubmed-meshheading:12721352-Infant,
pubmed-meshheading:12721352-Knee Joint,
pubmed-meshheading:12721352-Middle Aged,
pubmed-meshheading:12721352-Mitochondria,
pubmed-meshheading:12721352-Osteoarthritis,
pubmed-meshheading:12721352-Telomerase,
pubmed-meshheading:12721352-Telomere,
pubmed-meshheading:12721352-Thymidine,
pubmed-meshheading:12721352-Transduction, Genetic,
pubmed-meshheading:12721352-beta-Galactosidase
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pubmed:year |
2003
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pubmed:articleTitle |
The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair.
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pubmed:affiliation |
Department of Orthopaedics, University of Iowa College of Medicine, Iowa City 52242, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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