Linked Life Data

12720135

Source:http://linkedlifedata.com/resource/pubmed/id/12720135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-4-29
pubmed:abstractText
Waldenstrom's macroglobulinemia (WM) is a poorly characterized B-cell lymphoproliferative disorder. There are a relatively limited number of detailed clinicopathological assessments, while the majority of clinical trials have been nonrandomized, single-institution phase II studies. Unfortunately progress in this disorder has been hindered by a lack of universally accepted diagnostic criteria. It is clear that criteria incorporating clinical, morphological, immunophenotypic, and, ultimately, genotypic parameters are needed for future clinical trails. Following a detailed clinicopathological assessment of 111 patients and a review of the published literature the following diagnostic criteria were proposed for WM: IgM monoclonal gammopathy of any concentration, bone marrow infiltration by small lymphocytes, plasmacytoid cells and plasma cells in a diffuse, interstitial or nodular pattern, and a surface Ig(+)CD19(+)CD20(+)CD5(-)CD10(-)CD23(-) immunophenotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0093-7754
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Elsevier Inc. All rights reserved.
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
196-200
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Developing diagnostic criteria in Waldenstrom's macroglobulinemia.
pubmed:affiliation
HMDS Laboratory, The General Infirmary at Leeds, Leeds, UK.
pubmed:publicationType
Journal Article