| pubmed-article:12718937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0023690 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C1413221 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:12718937 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:12718937 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12718937 | pubmed:dateCreated | 2003-4-29 | lld:pubmed |
| pubmed-article:12718937 | pubmed:abstractText | CD38 signaling, either induced by ligation with specific agonistic monoclonal antibody (mAb) or after interaction with CD31, its cognate counter-receptor, is involved in release of IL-1beta, IL-6, and IL-10 cytokines in resting human monocytes. CD38 ligation by the F(ab')(2) IB4 mAb did not induce signals relevant for cytokine secretion and the block of the Fcgamma receptor I (FcgammaRI) by anti-CD64 or FcgammaRII by anti-CD32 mAb did not inhibit CD38-mediated IL-1beta release. Dimerization or multimerization of the CD38 molecule by: (i) cross-linking of the receptor ligated by F(ab')(2) or by (ii) increasing CD38 expression by treating monocytes with IFNgamma were able to restore the truncated CD38-mediated signals involved in cytokine secretion. These data indicate that CD38 receptor-mediated signals operate directly suggesting a Fcgamma receptorial surface molecule independent activation pathway. The key element for the receptor mediated signaling is represented by surface density of CD38 on resting monocytes. | lld:pubmed |
| pubmed-article:12718937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12718937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12718937 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12718937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12718937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12718937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12718937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12718937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12718937 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12718937 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:MalavasiFabio... | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:DeaglioSilvia... | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:FunaroAdaA | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:AusielloClara... | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:UrbaniFrances... | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:LandeRobertoR | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:12718937 | pubmed:author | pubmed-author:SconocchiaGiu... | lld:pubmed |
| pubmed-article:12718937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12718937 | pubmed:volume | 220 | lld:pubmed |
| pubmed-article:12718937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12718937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12718937 | pubmed:pagination | 30-8 | lld:pubmed |
| pubmed-article:12718937 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12718937 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12718937 | pubmed:articleTitle | CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes. | lld:pubmed |
| pubmed-article:12718937 | pubmed:affiliation | Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanitá, 00161, Rome, Italy | lld:pubmed |
| pubmed-article:12718937 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12718937 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12718937 | lld:pubmed |
