|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021753,
umls-concept:C0021760,
umls-concept:C0023690,
umls-concept:C0026473,
umls-concept:C0032214,
umls-concept:C0035253,
umls-concept:C0035820,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0085295,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0439851,
umls-concept:C0600138,
umls-concept:C1413221,
umls-concept:C1552596,
umls-concept:C1947931
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2003-4-29
|
|
pubmed:abstractText |
CD38 signaling, either induced by ligation with specific agonistic monoclonal antibody (mAb) or after interaction with CD31, its cognate counter-receptor, is involved in release of IL-1beta, IL-6, and IL-10 cytokines in resting human monocytes. CD38 ligation by the F(ab')(2) IB4 mAb did not induce signals relevant for cytokine secretion and the block of the Fcgamma receptor I (FcgammaRI) by anti-CD64 or FcgammaRII by anti-CD32 mAb did not inhibit CD38-mediated IL-1beta release. Dimerization or multimerization of the CD38 molecule by: (i) cross-linking of the receptor ligated by F(ab')(2) or by (ii) increasing CD38 expression by treating monocytes with IFNgamma were able to restore the truncated CD38-mediated signals involved in cytokine secretion. These data indicate that CD38 receptor-mediated signals operate directly suggesting a Fcgamma receptorial surface molecule independent activation pathway. The key element for the receptor mediated signaling is represented by surface density of CD38 on resting monocytes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Biopolymers,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fab Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0008-8749
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
220
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
30-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12718937-ADP-ribosyl Cyclase,
pubmed-meshheading:12718937-Antibodies, Monoclonal,
pubmed-meshheading:12718937-Antigens, CD,
pubmed-meshheading:12718937-Antigens, CD31,
pubmed-meshheading:12718937-Antigens, CD38,
pubmed-meshheading:12718937-Biopolymers,
pubmed-meshheading:12718937-Cell Line,
pubmed-meshheading:12718937-Dimerization,
pubmed-meshheading:12718937-Humans,
pubmed-meshheading:12718937-Immunoglobulin Fab Fragments,
pubmed-meshheading:12718937-Interferon-gamma,
pubmed-meshheading:12718937-Interleukin-1,
pubmed-meshheading:12718937-Interleukin-10,
pubmed-meshheading:12718937-Interleukin-6,
pubmed-meshheading:12718937-Membrane Glycoproteins,
pubmed-meshheading:12718937-Monocytes,
pubmed-meshheading:12718937-Receptors, IgG,
pubmed-meshheading:12718937-Signal Transduction
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes.
|
|
pubmed:affiliation |
Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanitá, 00161, Rome, Italy
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
