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pubmed-article:12717360pubmed:abstractTextIsolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF) and melphalan for advanced extremity malignancies achieves significant complete response rates. To study molecular mechanisms underlying this response, a nude rat ILP model with a human melanoma xenograft was developed.lld:pubmed
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pubmed-article:12717360pubmed:articleTitleA human melanoma xenograft in a nude rat responds to isolated limb perfusion with TNF plus melphalan.lld:pubmed
pubmed-article:12717360pubmed:affiliationDivision of Surgical Oncology, Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.lld:pubmed
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