Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-28
pubmed:abstractText
Rats were subjected to unpredictable chronic stress (UCS), which was composed of 3 cycles of 7 kinds of stress for 21 days. Rats given UCS exhibited a depressive state in behavioral tests such as emergence tests and forced swim tests. Administration of cyclosporine-A (CsA), an immunosuppressive drug, gave rise to antidepressant effect in rats under the UCS, but not in stress-free rats. In other words, CsA shortened both the latency time in emergence tests and the immobility time in forced swim tests in rats given UCS. Analysis of brain tissue by HPLC revealed that CsA caused a significant increase in NE, 5-HT and 5-HIAA levels in the cortex of UCS treated rats, but treatment with either UCS or CsA alone resulted in the opposite effect. Comparing the data of monoamines and their metabolites in the brain, cascades may be different between CsA and imipramine, although both of them showed antidepressive effect in behavioral tests.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1342-8810
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-100
pubmed:dateRevised
2010-4-12
pubmed:meshHeading
pubmed-meshheading:12715925-Adrenal Glands, pubmed-meshheading:12715925-Analysis of Variance, pubmed-meshheading:12715925-Animals, pubmed-meshheading:12715925-Antidepressive Agents, pubmed-meshheading:12715925-Behavior, pubmed-meshheading:12715925-Biogenic Monoamines, pubmed-meshheading:12715925-Chronic Disease, pubmed-meshheading:12715925-Cyclosporine, pubmed-meshheading:12715925-Dose-Response Relationship, Drug, pubmed-meshheading:12715925-Frontal Lobe, pubmed-meshheading:12715925-Imipramine, pubmed-meshheading:12715925-Immunosuppressive Agents, pubmed-meshheading:12715925-Injections, Intraperitoneal, pubmed-meshheading:12715925-Male, pubmed-meshheading:12715925-Motor Activity, pubmed-meshheading:12715925-Organ Size, pubmed-meshheading:12715925-Rats, pubmed-meshheading:12715925-Rats, Inbred F344, pubmed-meshheading:12715925-Reaction Time, pubmed-meshheading:12715925-Stress, Physiological
pubmed:year
2003
pubmed:articleTitle
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
pubmed:affiliation
Department of Pathology and Immunology, Tokyo Medical and Dental University Graduate School, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't