Linked Life Data

12698562

Source:http://linkedlifedata.com/resource/pubmed/id/12698562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-4-17
pubmed:abstractText
The thermostable endogenous cysteine proteinase inhibitors (CPI) from the primary (REF), immortal (clone IE5) and transformed (clones trF8 and trF8nmcc) fibroblasts were isolated. All the isolated CPI act as reversible competitive inhibitors of cathepsins B and L and of papain. The study of inhibition of cathepsins B and L, purified from the same cell cultures as the CPI, showed that the Ki values for CPI from the cultures of immortal and transformed cells were by one order higher than the Ki values for CPI of primary fibroblasts. The data obtained suggest that immortalization and transformation alter the CPI properties.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
[Characterization of cysteine proteinase endogenous inhibitors obtained from transformed fibroblasts].
pubmed:affiliation
Institute of Biomedical Chemistry Russian Academy of Medical Sciences (RAMS), Pogodinskaya St. 10, Moscow, 119121 Russia.
pubmed:publicationType
Journal Article, English Abstract