|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002199,
umls-concept:C0010802,
umls-concept:C0023473,
umls-concept:C0025723,
umls-concept:C0035647,
umls-concept:C0127400,
umls-concept:C0871261,
umls-concept:C1154383,
umls-concept:C1363844,
umls-concept:C1550147,
umls-concept:C1570804,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1979963,
umls-concept:C2003903,
umls-concept:C2911692
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-4-16
|
|
pubmed:abstractText |
Cadherin-13 (CDH13) is a newly characterized cadherin molecule responsible for selective cell recognition and adhesion, the expression of which is decreased by methylation in a variety of human cancers, indicating that the CDH13 gene functions as a tumor suppressor gene. Although defective progenitor-stromal adhesion is a well-recognized feature of chronic myeloid leukemia (CML), the role of CDH13 abnormalities has not been evaluated in this disease.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
pubmed-author:BoqueConcepcionC,
pubmed-author:CastillejoJuan AJA,
pubmed-author:CervantesFranciscoF,
pubmed-author:ColomerDolorsD,
pubmed-author:GrañenaAlbertA,
pubmed-author:HeinigerAnabelA,
pubmed-author:HermosinLourdesL,
pubmed-author:JimenezAntonioA,
pubmed-author:LeonAngelA,
pubmed-author:Roman-GomezJoseJ,
pubmed-author:TorresAntonioA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1472-9
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12697869-Adult,
pubmed-meshheading:12697869-Antineoplastic Agents,
pubmed-meshheading:12697869-Cadherins,
pubmed-meshheading:12697869-Calcium,
pubmed-meshheading:12697869-Female,
pubmed-meshheading:12697869-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12697869-Gene Silencing,
pubmed-meshheading:12697869-Genes, Tumor Suppressor,
pubmed-meshheading:12697869-Humans,
pubmed-meshheading:12697869-Interferon-alpha,
pubmed-meshheading:12697869-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:12697869-Male,
pubmed-meshheading:12697869-Methylation,
pubmed-meshheading:12697869-Middle Aged,
pubmed-meshheading:12697869-Multivariate Analysis,
pubmed-meshheading:12697869-Polymerase Chain Reaction,
pubmed-meshheading:12697869-Predictive Value of Tests,
pubmed-meshheading:12697869-Prognosis,
pubmed-meshheading:12697869-Promoter Regions, Genetic,
pubmed-meshheading:12697869-Proportional Hazards Models,
pubmed-meshheading:12697869-RNA, Messenger,
pubmed-meshheading:12697869-Risk Factors,
pubmed-meshheading:12697869-Survival Analysis
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa.
|
|
pubmed:affiliation |
Hematology Department, Reina Sofia Hospital, Avda, Menendez Pidal s/n, 14004 Cordoba, Spain. peperosa@teleline.es
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
