Linked Life Data

12692403

Source:http://linkedlifedata.com/resource/pubmed/id/12692403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-14
pubmed:abstractText
Effects of stimulation of the maternal immune system on abnormal pregnancy induced with 5-azacytidine (5ACDR) administration at embryonic day 7.5 (E7.5) were examined in mice treated with recombinant interleukin 1beta (IL-1beta) at E6.5 (5ACDR + IL-1 at E6.5) or E9.5 (5ACDR + IL-1 at E9.5), OK432 (5ACDR + OK432) at E7.5 or PSK (5ACDR + PSK) at E7.5. Embryos from these dams were examined at E13.5. The frequency of dead and malformed embryos and number of malformations on each embryo increased in the 5ACDR + IL-1 at E6.5 groups compared with the 5ACDR-alone group. Adverse pregnancy outcomes in the 5ACDR + OK432 and 5ACDR + PSK groups were less frequent than in the 5ACDR-alone group. The frequency of exencephaly, facial cleft, eye anomalies (micro- or anophthalmos), and micrognathia significantly increased in the 5ACDR + IL-1 groups, in contrast, that of exencephaly decreased in the 5ACDR + OK432 and 5ACDR + PSK groups compared with the 5ACDR-alone group. The phagocytes on the exencephalic surface drastically increased in the 5ACDR + IL-1 groups, and they often appeared to ingest the migrating neuroepithelial cells. Such findings, however, were rarely observed in the 5ACDR-alone, 5ACDR + OK432 and 5ACDR + PSK groups. Thus, administration of IL-1beta to the abnormal pregnant dams increased the mortality and severity of the malformations in the embryos caused by 5ACDR, whereas PSK or OK432 decreased them. These results suggest that the different modes of activation of the maternal immune system may exert alternative or opposite effects on teratogenic pregnancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0914-3505
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-56
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12692403-Abnormalities, Multiple, pubmed-meshheading:12692403-Adjuvants, Immunologic, pubmed-meshheading:12692403-Animals, pubmed-meshheading:12692403-Antimetabolites, Antineoplastic, pubmed-meshheading:12692403-Antineoplastic Agents, pubmed-meshheading:12692403-Azacitidine, pubmed-meshheading:12692403-Body Weight, pubmed-meshheading:12692403-Brain, pubmed-meshheading:12692403-Congenital Abnormalities, pubmed-meshheading:12692403-Female, pubmed-meshheading:12692403-Interleukin-1, pubmed-meshheading:12692403-Mice, pubmed-meshheading:12692403-Mice, Inbred ICR, pubmed-meshheading:12692403-Microscopy, Electron, Scanning, pubmed-meshheading:12692403-Phagocytes, pubmed-meshheading:12692403-Picibanil, pubmed-meshheading:12692403-Placenta, pubmed-meshheading:12692403-Pregnancy, pubmed-meshheading:12692403-Pregnancy, Animal, pubmed-meshheading:12692403-Proteoglycans, pubmed-meshheading:12692403-Teratogens, pubmed-meshheading:12692403-Time Factors
pubmed:year
2003
pubmed:articleTitle
Opposite effects of the maternal immune system activated by interleukin-1beta vs. PSK and OK432 on 5-azacytidine-induced birth defects.
pubmed:affiliation
Department of Anatomy, Shimane Medical University, Izumo, Shimane 693-8501, Japan. thatta@shimane-med.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't