| pubmed-article:12686372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C0035871 | lld:lifeskim |
| pubmed-article:12686372 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12686372 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12686372 | pubmed:dateCreated | 2003-4-10 | lld:pubmed |
| pubmed-article:12686372 | pubmed:abstractText | Chronic rotenone exposure reproduces features of Parkinson's disease (PD) (Nat. Neurosci. 3 (2000) 1301; Exp. Neurol. 179 (2003) 9). We investigated the role of glial activation in rotenone toxicity in vivo. Male Lewis rats received 2-3 mg/kg rotenone per day for up to 4 weeks. In 50% of surviving rotenone-treated animals, there was nigrostriatal dopaminergic degeneration, marked by reduced tyrosine hydroxylase immunoreactivity). Extensive microglial activation, determined by OX-42-ir, occurred in striatum and nigra of rotenone-treated animals, and was prominent before anatomical evidence of dopaminergic lesions. Microglia enlarged and developed short, stubby processes in rotenone-treated animals. Rotenone-induced microglial activation was less pronounced in cortex. Reactive astrocytosis was minimal and limited to a thin rim around the lesion. Marked microglial activation with minimal astrocytosis is another pathological feature of PD reproduced by rotenone treatment. | lld:pubmed |
| pubmed-article:12686372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12686372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12686372 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12686372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12686372 | pubmed:month | May | lld:pubmed |
| pubmed-article:12686372 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:12686372 | pubmed:author | pubmed-author:KimJin HoJH | lld:pubmed |
| pubmed-article:12686372 | pubmed:author | pubmed-author:GreenamyreJ... | lld:pubmed |
| pubmed-article:12686372 | pubmed:author | pubmed-author:BetarbetRanji... | lld:pubmed |
| pubmed-article:12686372 | pubmed:author | pubmed-author:ShererTodd... | lld:pubmed |
| pubmed-article:12686372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12686372 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12686372 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:12686372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12686372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12686372 | pubmed:pagination | 87-90 | lld:pubmed |
| pubmed-article:12686372 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12686372 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12686372 | pubmed:articleTitle | Selective microglial activation in the rat rotenone model of Parkinson's disease. | lld:pubmed |
| pubmed-article:12686372 | pubmed:affiliation | Center for Neurodegenerative Disease, Emory University, 30322, Atlanta, GA, USA. | lld:pubmed |
| pubmed-article:12686372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12686372 | pubmed:publicationType | Comparative Study | lld:pubmed |
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