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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-4-10
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pubmed:abstractText |
Chronic rotenone exposure reproduces features of Parkinson's disease (PD) (Nat. Neurosci. 3 (2000) 1301; Exp. Neurol. 179 (2003) 9). We investigated the role of glial activation in rotenone toxicity in vivo. Male Lewis rats received 2-3 mg/kg rotenone per day for up to 4 weeks. In 50% of surviving rotenone-treated animals, there was nigrostriatal dopaminergic degeneration, marked by reduced tyrosine hydroxylase immunoreactivity). Extensive microglial activation, determined by OX-42-ir, occurred in striatum and nigra of rotenone-treated animals, and was prominent before anatomical evidence of dopaminergic lesions. Microglia enlarged and developed short, stubby processes in rotenone-treated animals. Rotenone-induced microglial activation was less pronounced in cortex. Reactive astrocytosis was minimal and limited to a thin rim around the lesion. Marked microglial activation with minimal astrocytosis is another pathological feature of PD reproduced by rotenone treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD147,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bsg protein, Gallus gallus,
http://linkedlifedata.com/resource/pubmed/chemical/Bsg protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rotenone,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
341
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12686372-Animals,
pubmed-meshheading:12686372-Antigens, CD,
pubmed-meshheading:12686372-Antigens, CD147,
pubmed-meshheading:12686372-Antigens, Neoplasm,
pubmed-meshheading:12686372-Antigens, Surface,
pubmed-meshheading:12686372-Astrocytes,
pubmed-meshheading:12686372-Avian Proteins,
pubmed-meshheading:12686372-Blood Proteins,
pubmed-meshheading:12686372-Corpus Striatum,
pubmed-meshheading:12686372-Disease Models, Animal,
pubmed-meshheading:12686372-Environmental Exposure,
pubmed-meshheading:12686372-Glial Fibrillary Acidic Protein,
pubmed-meshheading:12686372-Immunohistochemistry,
pubmed-meshheading:12686372-Insecticides,
pubmed-meshheading:12686372-Male,
pubmed-meshheading:12686372-Membrane Glycoproteins,
pubmed-meshheading:12686372-Microglia,
pubmed-meshheading:12686372-Parkinson Disease,
pubmed-meshheading:12686372-Rats,
pubmed-meshheading:12686372-Rats, Inbred Lew,
pubmed-meshheading:12686372-Rotenone,
pubmed-meshheading:12686372-Substantia Nigra,
pubmed-meshheading:12686372-Tyrosine 3-Monooxygenase
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pubmed:year |
2003
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pubmed:articleTitle |
Selective microglial activation in the rat rotenone model of Parkinson's disease.
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pubmed:affiliation |
Center for Neurodegenerative Disease, Emory University, 30322, Atlanta, GA, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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