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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-9
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pubmed:abstractText |
5-Fluorouracil (5-FU) is an anticancer agent clinically used against various cancers including renal cell carcinoma (RCC). 5-FU inhibits thymidylate synthase (TS) and blocks DNA synthesis. TS is the key enzyme in the catalysis of the methylation from dUMP to dTMP in the DNA synthetic process. Little is known about the significance of TS in RCC. We investigated the activity of TS in 68 RCCs and the association with dihydropyrimidine dehydrogenase (DPD) activities, which is a principal enzyme in the degradation of 5-FU and pyrimidine nucleotides. The relationship between TS/DPD activities in primary cultured RCC cell lines and their sensitivity to 5-FU was also examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1453-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12684419-Adult,
pubmed-meshheading:12684419-Aged,
pubmed-meshheading:12684419-Aged, 80 and over,
pubmed-meshheading:12684419-Antimetabolites, Antineoplastic,
pubmed-meshheading:12684419-Carcinoma, Renal Cell,
pubmed-meshheading:12684419-Cell Line, Tumor,
pubmed-meshheading:12684419-Cells, Cultured,
pubmed-meshheading:12684419-Coloring Agents,
pubmed-meshheading:12684419-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:12684419-Disease Progression,
pubmed-meshheading:12684419-Female,
pubmed-meshheading:12684419-Fluorouracil,
pubmed-meshheading:12684419-Humans,
pubmed-meshheading:12684419-Kidney,
pubmed-meshheading:12684419-Kidney Neoplasms,
pubmed-meshheading:12684419-Male,
pubmed-meshheading:12684419-Middle Aged,
pubmed-meshheading:12684419-Protein Binding,
pubmed-meshheading:12684419-Pyrimidines,
pubmed-meshheading:12684419-Tetrazolium Salts,
pubmed-meshheading:12684419-Thiazoles,
pubmed-meshheading:12684419-Thymidylate Synthase,
pubmed-meshheading:12684419-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Significance of thymidylate synthase activity in renal cell carcinoma.
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pubmed:affiliation |
Department of Urology, Kyoto Prefectural University of Medicine, Kyoto 602-8566. ymizutan@koto.kpu-m.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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